The Role Of Leptin And Its Effects On The Reproductive...

Role of leptin in PCOS. Leptin is a hormone secreted mainly from the adipose tissue, serum levels of which are influenced by obesity, insulin resistance and the levels of sex steroids (androgens and estrogens) and insulin. It is mainly involved in the regulation of body weight by decreasing appetite and increasing energy expenditure. Besides regulating the energy metabolism of the body, leptin has important actions on the reproductive system, which makes it an important link between the adipose tissue and hypothalamus– pituitary–gonadal (HPG) axis (2). Long-term hyperinsulinemia in humans, as is the case in PCOS patients, stimulates leptin secretion from adipose tissue (9). Significantly higher leptin (P = 0.0028), and insulin concentrations, insulin: glucose ratio (IGR), and a significant correlation between leptin and fasting insulin concentrations, IGR, WHR and LH have been reported in obese PCOS women than in normal-weight women with PCOS. There is a significant neg ative correlation between leptin and LH concentrations, independently of either BMI or IGR, suggesting a possible involvement of leptin in LH hypersecretion (10). Estrogens increase, whereas androgens suppress leptin production, suggesting sexual dimorphism in leptin levels (2). The direct and indirect effects of leptin on the HPG axis, such as acceleration of GnRH pulsatility (but not the pulse amplitude) in a dose dependent manner, suggest that leptin may play an important role in the pathogenesis of PCOS.Show MoreRelatedMechanisms By Which Obesity Affect Ovarian Function1644 Words   |  7 Pageshave demonstrated that obesity leads to ovarian dysfunction through oxidative and ER stress and inflammation (26,65,66,74-78). Obesity leads to excess lipids, glucose, insulin, and leptin in variety of ovarian cells including: granulosa cells, cumulus cells, oocytes, and early embryos (ref more;(65,79,80)). 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